diff --git a/src/core/init.c b/src/core/init.c
index 6b5cf60c..b5a9763e 100644
--- a/src/core/init.c
+++ b/src/core/init.c
@@ -181,6 +181,9 @@
 #if LWIP_TCP && LWIP_NETIF_TX_SINGLE_PBUF && !TCP_OVERSIZE
   #error "LWIP_NETIF_TX_SINGLE_PBUF needs TCP_OVERSIZE enabled to create single-pbuf TCP packets"
 #endif
+#if IP_FRAG && IP_FRAG_USES_STATIC_BUF && LWIP_NETIF_TX_SINGLE_PBUF
+  #error "LWIP_NETIF_TX_SINGLE_PBUF does not work with IP_FRAG_USES_STATIC_BUF==1 as that creates pbuf queues"
+#endif
 
 
 /* Compile-time checks for deprecated options.